Alfavīrusu vektoru transdukcijas efektivitātes paaugstināšana ar magnētiskām nanodaļiņām vēža šūnās

6533b860fe1ef96bd12c342d

RESEARCH PRODUCT

Alfavīrusu vektoru transdukcijas efektivitātes paaugstināšana ar magnētiskām nanodaļiņām vēža šūnās

Jeļena Sorokina

subject

audzēju šūnas alfavīrusi magnētiskās nanodaļiņas (MNPs)Bioloģija Semliki meža vīruss (SFV)

description

Pēdējā laikā alfavīrusu vektoru pielietojums pretvēža terapijā eksperimentālos modeļos kļūst arvien izplatītāks. Semliki meža vīruss (SFV) ir potenciāls vēža gēnu terapijas vektors, kas spēj nodrošināt relatīvi īslaicīgu, bet augsta līmeņa heterologu proteīnu ekspresiju vēža šūnās. Transdukcijas efektivitātei ir liela nozīme optimālai gēnu piegādei audzējos. Ir pierādīts, ka magnētiskās nanodaļiņas (MNPs) palielina šūnu transdukciju ar dažādiem vīrusu vektoriem in vitro. Šajā darbā tika pētīts MNPs panelis, lai uzlabotu vēža šūnu transdukciju ar SFV vektoru. Tika pielietota magnetotransdukcija, izmantojot pozitīvi lādētas MNPs, kas palielina Semliki meža vīrusa transdukciju TS/A, B16, 4T1, un Huh-7 šūnu līnijās in vitro fetālā seruma klātbūtnē. Pozitīvi lādētās MNPs efektīvi uzņēma SFV daļiņas, neatkarīgi no izmantotās barotnes, un MNPs-SFV kompleksi tika veiksmīgi atdalīti no suspensijas ar magnētisko izgulsnēšanu. Iegūtie rezultāti atklāja MNPs iespējamo pielietojumu uzlabotai SFV vektoru piegādei.

year	journal	country	edition	language
2019-01-01

https://dspace.lu.lv/dspace/handle/7/48280

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