6533b860fe1ef96bd12c38c1

RESEARCH PRODUCT

Silica-supported HgSO4/H2SO4: a convenient reagent for the hydration of alkynes under mild conditions

María Elena González NúñezRossella MelloAna Alcalde-aragonés

subject

Solventchemistry.chemical_compoundchemistryReagentOrganic ChemistryDrug DiscoveryInorganic chemistryOrganic chemistrychemistry.chemical_elementBiochemistryDichloromethaneCatalysisMercury (element)

description

Abstract The silica-supported aqueous-phase catalyst (SAPC) approach has proven convenient for efficiently performing the hydration of alkynes with HgSO 4 /H 2 SO 4 to give the corresponding carbonyl compounds in dichloromethane under mild conditions. The use of this solid reagent significantly improves the reaction work-up as it merely involves filtering and evaporating the solvent.

https://doi.org/10.1016/j.tetlet.2010.06.042