6533b860fe1ef96bd12c3938
RESEARCH PRODUCT
Improved column-based radiochemical processing of the generator produced 68Ga.
Konstantin ZhernosekovKonstantin ZhernosekovD.v. FilosofovFrank RöschT. WagnerA.n. BelozubAndreas TürlerAndreas TürlerAndreas TürlerNatalia Loktionovasubject
chemistry.chemical_compoundRadiationChromatographyAqueous solutionGenerator (computer programming)chemistryIon exchangeElutionExtraction (chemistry)AcetoneHydrochloric acidRadionuclide Generatordescription
An improved chemical strategy for processing of the generator produced (68)Ga was developed based on processing of the original (68)Ge/(68)Ga generator eluate on a micro-column. Direct pre-concentration and purification of the eluted (68)Ga is performed on a cation-exchange resin in hydrochloric acid/acetone media. A supplementary step based on a second micro-column filled with a second resin allows direct re-adsorption of (68)Ga eluted from the cation exchanger. (68)Ga is finally striped from the second resin with a small volume of pure water. For this purpose a strong anion exchanger and a novel extraction chromatographic resin based on tetraalkyldiglycolamides are characterized. The strategy allows online pre-concentration and purification of (68)Ga from the original generator eluate. The supplementary column allows transferring (68)Ga with high radionuclide and chemical quality in the aqueous solution with small volume and low acidity useful for direct radiolabeling reactions.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2011-07-01 | Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine |