Recovery from chronic diseases of consciousness: State of the art in neuromodulation for persistent vegetative state and minimally conscious state

6533b860fe1ef96bd12c3990

RESEARCH PRODUCT

Recovery from chronic diseases of consciousness: State of the art in neuromodulation for persistent vegetative state and minimally conscious state

Gaetano Pappalardo Jun Zhong Giuseppe Barbagallo Massimiliano Visocchi Giuseppe La Rocca Pier Paolo Mattogno Francesco Signorelli Gerardo Iacopino

subject

Modern medicine Deep brain stimulation media_common.quotation_subject medicine.medical_treatment Deep Brain Stimulation Altered state of consciousness DBS 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine DBS; Disorders of consciousness; Minimally conscious state; Neuromodulation; SCS; Vegetative state; Surgery; Neurology (clinical)medicine Humans Minimally conscious state media_common Persistent vegetative state Disorders of consciousness Spinal Cord Stimulation Vegetative state business.industry Settore MED/27 - Neurochirurgia Neuromodulation Persistent Vegetative State Minimally conscious state medicine.disease Neuromodulation (medicine)Cerebral hemodynamics Surgery Neurology (clinical)Consciousness business Neuroscience 030217 neurology & neurosurgery SCS

description

Chronic diseases of consciousness (CDC) can still be considered a challenging frontier for modern medicine, probably because of their not completely understood physiopathological mechanisms. Following encouraging evidence on cerebral hemodynamics, some authors have hypothesized a role for neuromodulation in the treatment of CDC patients. In the past 40 years, spinal cord stimulation (SCS) and deep brain stimulation (DBS) have been used experimentally for the treatment of patients in a severe altered state of consciousness, with some interesting but not conclusive results. The present review summarizes the data currently available in the literature on this particular and debated topic. On these grounds, further clinical studies are needed to better understand the altered dynamics of neuronal network circuits in CDC patients as a step towards novel therapeutic strategies.

year	journal	country	edition	language
2017-01-01

10.1007/978-3-319-39546-3_4 http://hdl.handle.net/20.500.11769/309896

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