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RESEARCH PRODUCT

Systemic Inflammation in Metabolic Syndrome: Increased Platelet and Leukocyte Activation, and Key Role of CX3CL1/CX3CR1 and CCL2/CCR2 Axes in Arterial Platelet-Proinflammatory Monocyte Adhesion

Patrice MarquesSergio Martínez HervasEsther BenitoAida ColladoAida ColladoElena DomingoElena DomingoMaria-jesus SanzMaria-jesus SanzLaura PiquerasLaura PiquerasJosé T. RealJuan F. Ascaso

subject

CCR2Chemokinelcsh:Medicinechemokines030204 cardiovascular system & hematologySystemic inflammationArticlemetabolic syndromeendothelial dysfunctionProinflammatory cytokine03 medical and health sciences0302 clinical medicineleukocyte activationmedicineplatelet activationPlatelet activationEndothelial dysfunction030304 developmental biologysystemic inflammation0303 health sciencesbiologybusiness.industryMonocytelcsh:RGeneral Medicinemedicine.diseasecytokinesmedicine.anatomical_structureImmunologybiology.proteinTumor necrosis factor alphamedicine.symptombusiness

description

Background: Metabolic syndrome is associated with low-grade systemic inflammation, which is a key driver of premature atherosclerosis. We characterized immune cell behavior in metabolic syndrome, its consequences, and the potential involvement of the CX3CL1/CX3CR1 and CCL2/CCR2 chemokine axes. Methods: Whole blood from 18 patients with metabolic syndrome and 21 age-matched controls was analyzed by flow cytometry to determine the leukocyte immunophenotypes, activation, platelet-leukocyte aggregates, and CX3CR1 expression. ELISA determined the plasma marker levels. Platelet-leukocyte aggregates adhesion to tumor necrosis factor-&alpha

yearjournalcountryeditionlanguage
2019-05-01Journal of Clinical Medicine
10.3390/jcm8050708http://dx.doi.org/10.3390/jcm8050708