6533b860fe1ef96bd12c39c8

RESEARCH PRODUCT

Quantitative and Qualitative Platelet Derangements in Cardiac Surgery and Extracorporeal Life Support

Enrico SquiccimarroEnrico SquiccimarroEnrico SquiccimarroDomenico PaparellaFederica JiritanoFederica JiritanoGiuseppe Filiberto SerrainoHugo Ten CateHugo Ten CateRoberto Lorusso

subject

medicine.medical_specialtyPlatelet disorderbiological prosthesisRESPIRATORY-FAILUREProsthesis Implantationlcsh:MedicinethrombocytopeniaReview030204 cardiovascular system & hematologyextracorporeal life supportExtracorporeallaw.invention03 medical and health sciences0302 clinical medicinelawInternal medicineCardiopulmonary bypassmedicinePlatelet030304 developmental biologyplateletUNFRACTIONATED HEPARIN0303 health sciencesCARDIOPULMONARY BYPASSbusiness.industrylcsh:RMEMBRANE-OXYGENATIONACTIVATED PLATELETSGeneral MedicineHypothermiaENDOTHELIAL-CELLSANTIBODY-FORMATIONCardiac surgeryinflammationCORONARY-ARTERY-BYPASSLife supportAORTIC-VALVE-REPLACEMENTCardiologyHEPARIN-INDUCED THROMBOCYTOPENIAmedicine.symptombusinesscardiac surgery

description

Thrombocytopenia and impaired platelet function are known as intrinsic drawbacks of cardiac surgery and extracorporeal life supports (ECLS). A number of different factors influence platelet count and function including the inflammatory response to a cardiopulmonary bypass (CPB) or to ECLS, hemodilution, hypothermia, mechanical damage and preoperative treatment with platelet-inhibiting agents. Moreover, although underestimated, heparin-induced thrombocytopenia is still a hiccup in the perioperative management of cardiac surgical and, above all, ECLS patients. Moreover, recent investigations have highlighted how platelet disorders also affect patients undergoing biological prosthesis implantation. Though many hypotheses have been suggested, the mechanism underlying thrombocytopenia and platelet disorders is still to be cleared. This narrative review aims to offer clinicians a summary of their major causes in the cardiac surgery setting.

yearjournalcountryeditionlanguage
2021-02-01Journal of Clinical Medicine
10.3390/jcm10040615https://doi.org/10.3390/jcm10040615