6533b860fe1ef96bd12c3ac0

RESEARCH PRODUCT

Relative Telomere Length and Cardiovascular Risk Factors

Tanja ZellerChristian P. MüllerBlankenberg StefanStefan NickelsPhilipp S. WildMahir KarakasMoritz KoriathIrene SchmidtmannThomas MünzelDirk WestermannSteffen RappNorbert PfeifferKarl J. LacknerManfred E. Beutel

subject

Malecardiovascular risk factorsmedicine.medical_specialtyCardiovascular risk factorsPopulationlcsh:QR1-502Disease030204 cardiovascular system & hematologyBiochemistryArticlelcsh:MicrobiologyBody Mass Index03 medical and health scienceschemistry.chemical_compound0302 clinical medicinecardiovascular diseaseInternal medicinetelomere lengthHumansMedicine030212 general & internal medicineeducationMolecular BiologyTriglyceridesAgededucation.field_of_studybusiness.industryCholesterolSmokingAge FactorsTelomere HomeostasisMiddle AgedtelomeresTelomereCholesterolEndocrinologyBlood pressurechemistryCardiovascular DiseasesageingAgeingFemalebusinessBody mass index

description

(1) Background: Telomeres are repetitive DNA sequences located at the extremities of chromosomes that maintain genetic stability. Telomere biology is relevant to several human disorders and diseases, specifically cardiovascular disease. To better understand the link between cardiovascular disease and telomere length, we studied the effect of relative telomere length (RTL) on cardiovascular risk factors in a large population-based sample. (2) Methods: RTL was measured by a real-time quantitative polymerase chain reaction in subjects of the population-based Gutenberg Health Study (n = 4944). We then performed an association study of RTL with known cardiovascular risk factors of smoking status as well as systolic and diastolic blood pressure, body mass index (BMI), LDL cholesterol, HDL cholesterol, and triglycerides. (3) Results: A significant correlation was shown for RTL, with age as a quality control in our study (effect = &minus

yearjournalcountryeditionlanguage
2019-05-17Biomolecules
https://doi.org/10.3390/biom9050192