Autoantibodies in experimental autoimmune hepatitis

6533b860fe1ef96bd12c3bd3

RESEARCH PRODUCT

Autoantibodies in experimental autoimmune hepatitis

Michael Manns Silvia Brunner A. Kyriatsoulis Ansgar W. Lohse Karl-hermann Meyer Zum Büschenfelde

subject

Male Pathology medicine.medical_specialty Blotting Western Fluorescent Antibody Technique Autoimmune hepatitis Hepatitis Animal medicine.disease_cause Autoimmune Diseases Autoimmunity Pathogenesis Mice Antigen Animals Medicine Autoantibodies Hepatitis Hepatology biology business.industry Autoantibody medicine.disease Mice Inbred C57BL Immunization Immunology biology.protein Antibody business

description

Experimental autoimmune hepatitis (EAH) can be induced in mice by immunization with syngeneic soluble liver antigens in complete Freund's adjuvant. It has previously been shown that autoreactive T cells play an important role in this animal model of autoimmune hepatitis. We have studied the occurrence of liver autoantibodies in EAH. Characteristic autoantibodies appeared several weeks after disease induction and antibody titres continued to rise when histological and biochemical signs of disease activity had already regressed. Autoantibodies in EAH seemed to recognize autoantigens other than those present in autoimmune chronic active hepatitis patients. We conclude that autoantibodies arise in experimental autoimmune hepatitis but that these autoantibodies do not play a critical role in the pathogenesis of the disease.

year	journal	country	edition	language
1992-01-01	Journal of Hepatology

https://doi.org/10.1016/0168-8278(92)90130-h

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