6533b860fe1ef96bd12c3ff7

RESEARCH PRODUCT

Role of beta3-adrenergic receptors in intestinal diseases

subject

description

The Inflammatory Bowel Diseases (IBD), characterized by a gastro-intestinal tract inflammation, are a global health-care problem due to their morbidity, mortality and the constant increase in their worldwide incidence. The available therapies are still not curative only providing temporary symptomatic relief and reduction in complications.Although etiology is still unclear, IBD results in an interplay of various factors among which impaired and/or inappropriate immune response toward intestinal bacteria. Increasing disease incidence link environmental triggers occurring during socioeconomic development to IBD, especially stress. In this work, we aimed to investigated the role of adrenergic stimulation on intestinal inflammation particularly on immune cell maturation and oxidative stress as previous findings of our team demonstrated an anti-inflammatory property of ADRB3 on myometrial cells and an antioxidant effect on macrophages.Results highlighted the immunomodulator property of ADRB3 acting on macrophages and lymphocytes maturation. We also involved oxidative stress reduction in the protective effect of ADRB3 on both acute and chronic intestinal inflammation.Considering the new findings highlighted, ADRB3 could be a promising therapeutic target in the management of IBD. Specific and early ADRB3 stimulation should also be interesting in the management other inflammatory diseases.