6533b861fe1ef96bd12c431c
RESEARCH PRODUCT
ChemInform Abstract: Cooperative Assistance in Bifunctional Organocatalysis: Enantioselective Mannich Reactions with Aliphatic and Aromatic Imines.
Nicolas ProbstÁDám MadarászImre PápaiArto ValkonenAntti J. NeuvonenKari RissanenPetri M. Pihkosubject
chemistry.chemical_compoundNucleophileThioureachemistryHydrogen bondOrganocatalysisEnantioselective synthesisMoietyGeneral MedicineBifunctionalCombinatorial chemistryCatalysisdescription
both of which contain a thiourea moiety (Scheme 1).The catalysts are capable of deprotonating suitable nucleo-philes, such as activated carbonyl compounds. This proton-transfer reaction generates an ion pair, which is composed ofthe protonated catalyst and the anionic nucleophile interact-ing through hydrogen bonds. At least one of the NH moietiesin the protonated catalyst is involved in activating theelectrophilic reaction partner.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2013-01-15 | ChemInform |