6533b861fe1ef96bd12c43f4
RESEARCH PRODUCT
Systematic Construction of Ternary Cocrystals by Orthogonal and Robust Hydrogen and Halogen Bonds
Kari RissanenFilip Topićsubject
Hydrogenkemiahalogen bondsSupramolecular chemistrychemistry.chemical_elementCrystal structure010402 general chemistrychemistry01 natural sciencesBiochemistryCocrystalCatalysisColloid and Surface ChemistryOrganic chemistryta116Halogen bond010405 organic chemistryChemistryHydrogen bondGeneral Chemistry0104 chemical sciencesternary cocrystalsCrystallographyvetyhydrogenHalogenTernary operationdescription
A carefully designed strategy is presented for the construction of ternary cocrystals, based on the orthogonality of two supramolecular interaction modes: hydrogen bonding between crown ethers and thioureas and the halogen bonding between thioureas and perfluorohalocarbons. Tested on a set comprising two crown ethers, two thioureas and five halogen bond donors, the strategy resulted in a high, 75% success rate, with 15/20 component combinations yielding at least one cocrystal. Crystal structure analysis revealed the interplay between the hydrogen and halogen bonding motifs, also shedding light on the variables affecting their formation. peerReviewed
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2016-01-01 |