6533b861fe1ef96bd12c4596
RESEARCH PRODUCT
Chronic ethanol feeding induces cellular antioxidants decrease and oxidative stress in rat peripheral nerves. Effect of S-adenosyl-L-methionine and N-acetyl-L-cysteine.
F Martinez-sorianoFrancisco Bosch-morellJ. Carlos Fernández-checaFrancisco J. RomeroAnna Colellsubject
Malemedicine.medical_specialtyS-AdenosylmethionineEthanol feedingmedicine.disease_causeBiochemistryAntioxidantsLipid peroxidationRats Sprague-Dawleychemistry.chemical_compoundFree radicalPhysiology (medical)Internal medicineMalondialdehydemedicineAnimalsPeripheral Nerveschemistry.chemical_classificationGlutathione PeroxidaseEthanolS-adenosyl-L-methionineEthanolGlutathione peroxidaseN-acetyl-L- cysteineNerveGlutathioneMalondialdehydeGlutathionePeripheralAcetylcysteineRatsMicroscopy ElectronOxidative StressEndocrinologychemistryBiochemistryGlutathione peroxidaseLipid PeroxidationEthanoOxidative stressdescription
Chronic ethanol feeding promotes oxidative stress in rat peripheral nerve. Malondialdehyde, a lipid peroxidation product, content increases in sciatic nerves of rats fed an ethanol-containing diet, when compared with pair-fed animals. Moreover, glutathione content and glutathione peroxidase activity in this same tissue decrease in ethanol-fed vs. pair-fed rats. S- adenosyl-L-methionine and N-acetyl-L-cysteine, both with possible therapeutic action on alcoholism, were tested in this animal model. Only N-acetyl-L- cysteine was able to normalize malondialdehyde content and to restore glutathione content and glutathione peroxidase activity, to values not significantly different from those of sciatic nerves from pair-fed animals. The reasons for the different effect of both substances tested is also discussed.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1998-08-01 | Free radical biologymedicine |