6533b861fe1ef96bd12c45c0
RESEARCH PRODUCT
One-Pot Synthesis of Polysubstituted Pyrrolidines from Aminonitriles
Nino MeyerTill OpatzFrank Wernersubject
Group (periodic table)ChemistryOrganic ChemistryOne-pot synthesisOrganic chemistryGeneral MedicinePyrrole derivativesCatalysisCarbaniondescription
α-Aminonitriles with a mono- or unsubstituted amino group as well as a-(alkylideneamino)nitriles can be employed as easily accessible α-aminocarbanion equivalents. Their α-deprotonation yields stabilized carbanions, whichundergo smooth 1,4-addition to α,β-unsaturated carbonyl compounds. The resulting δ-ketoα-aminonitriles can be reductively cyclized to form polysubstituted pyrrolidines.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2005-08-30 | Synthesis |