Temporal dynamics of hippocampal neurogenesis in chronic neurodegeneration.

6533b861fe1ef96bd12c466a

RESEARCH PRODUCT

Temporal dynamics of hippocampal neurogenesis in chronic neurodegeneration.

Nina L. Fransen Stefano Suzzi V. Hugh Perry Boris Fehse Diego Gomez-nicola Mariana Vargas-caballero Hussain Al-malki José Manuel García-verdugo Arantxa Cebrián-silla Kristoffer Riecken

subject

Adult Male Antimetabolites Antineoplastic Patch-Clamp Techniques Time Factors Prions Neurogenesis Genetic Vectors Hippocampus Tissue Banks Biology Hippocampal formation Hippocampus Creutzfeldt-Jakob Syndrome Prion Diseases Mice Young Adult Neural Stem Cells Alzheimer Disease variant CJD Neural Pathways medicine Animals Humans Aged Cell Proliferation Dentate gyrus Neurogenesis Neurodegeneration Cytarabine Neurodegenerative Diseases Original Articles Middle Aged medicine.disease Neural stem cell Mice Inbred C57BL Neuroanatomical Tract-Tracing Techniques adult neurogenesis Disease Models Animal Chronic Disease Dentate Gyrus Mossy Fibers Hippocampal Disease Progression Female Neurology (clinical)Alzheimer's disease Neuroscience Neural development Alzheimer’s disease

description

Increased neurogenesis has been reported in neurodegenerative disease, but its significance is unclear. In a mouse model of prion disease, Gomez-Nicola et al. detect increased neurogenesis in the dentate gyrus that partially counteracts neuronal loss. Targeting neurogenesis may have therapeutic potential.

year	journal	country	edition	language
2014-06-18	Brain : a journal of neurology

10.1093/brain/awu155 https://pubmed.ncbi.nlm.nih.gov/24941947

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