6533b861fe1ef96bd12c46a5
RESEARCH PRODUCT
Role of tumor-infiltrating lymphocytes in patients with solid tumors: Can a drop dig a stone?
Juan L. IovannaViviana BazanAntonio RussoR. MaraglianoLorena IncorvaiaValentina CalòAngela ListìGiuseppe BadalamentiDaniele FanaleBruno VincenziNadia Barracosubject
PD-L10301 basic medicinePrognosiSettore MED/06 - Oncologia Medica[SDV]Life Sciences [q-bio]medicine.medical_treatmentImmunologyPredictive significance[SDV.CAN]Life Sciences [q-bio]/Cancerchemical and pharmacologic phenomenaBiology03 medical and health sciencesLymphocytes Tumor-Infiltrating0302 clinical medicineImmune systemNeoplasmsImmune suppressionPD-1Biomarkers TumormedicineAnimalsHumansTumor microenvironmentTumor-infiltrating lymphocytesMelanomaImmunotherapyPrognosismedicine.diseaseImmune checkpoint3. Good healthImmunosurveillance030104 developmental biologyTumor microenvironment030220 oncology & carcinogenesisCancer cellTumor immunologyCancer researchImmunotherapy[SDV.MHEP]Life Sciences [q-bio]/Human health and pathologyTumor-infiltrating lymphocytes (TILs)description
International audience; In recent years, multiple strategies for eliciting anti-tumor immunity have been developed in different clinical studies. Currently, immunotherapy was clinically validated as effective treatment option for many tumors such as melanoma, non-small cell lung cancer (NSCLC) and renal cell carcinoma (RCC). Some surface receptors of immune cells, called immune checkpoint receptors, may inhibit activity of proinflammatory lymphocytes, following binding with specific ligands. Cancer cells exploit these mechanisms to inactivate tumor-infiltrating lymphocytes (TILs) to escape from immunosurveillance. Among the different tumor-infiltrating immune cell populations, including leucocytes, macrophages, dendritic cells and mast cells, TILs are considered a selected population of T-cells with a higher specific immunological reactivity against tumor cells than the non-infiltrating lymphocytes. In this review we will discuss the promising role of TILs as biomarkers reflecting the immune response to the tumor, describing their potential ability to predict the prognosis and clinical outcome of immunotherapy in some solid tumors.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2019-09-01 | Cellular Immunology |