6533b861fe1ef96bd12c4c5b

RESEARCH PRODUCT

IAPs and Resistance to Death Receptors in Cancer

Laurence DubrezLaurence DubrezSimone FuldaSimone Fulda

subject

RIPK1chemistry.chemical_compoundSignallingchemistryApoptosisNecroptosisRegulatorCancer researchNF-κBBiologyCell fate determinationXIAP

description

Since their identification in mammal cells, IAPs emerged have as potent regulators of death receptor signalling pathways, determining the cell fate in response to receptor stimulation. Among IAPs, cIAP1 and cIAP2 are active components of receptor-associated signalling complexes able to promote the activation of ubiquitin-dependent survival signalling pathways. For its part, XIAP is an important regulator of caspase activity, determining the apoptotic signalling pathway engaged after death receptor stimulation. The use of IAP antagonists is a promising strategy in order to overcome the resistance of tumor cells to death receptor stimulation.

yearjournalcountryeditionlanguage
2017-01-01
https://doi.org/10.1007/978-3-319-56805-8_3