6533b861fe1ef96bd12c4c63
RESEARCH PRODUCT
In vitro pharmacological evaluation of the dichloromethanol extract fromSchinus molle l.
Sara CalatayudL. MorenoE. Primo-yúferaBelén BeltránJuan V. EspluguesR. Bellosubject
PharmacologybiologyIleumBiological activityAnatomyPharmacologyPharmacognosybiology.organism_classificationSchinus molleGuinea pigchemistry.chemical_compoundmedicine.anatomical_structurechemistrymedicineSerotoninHistamineAcetylcholinemedicine.drugdescription
The pharmacological activity of the dichloromethanol extract of Schinus molle L. (SM-DCM) was analysed in in vitro models. Preincubation of the isolated guinea-pig ileum or rat uterus preparations with the extract (100 μg/mL) abolished the contractile effects of histamine and serotonin respectively. At the same dose, the extract partially reduced the contractile effects of acetylcholine on the isolated rat duodenum. A 10 μg/mL dose showed an inhibitory effect on histamine and serotonin, but not on acetylcholine-induced contractions (NS). No significant effect was found with a 1 μg/mL dose. © 1998 John Wiley & Sons, Ltd.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1998-11-01 | Phytotherapy Research |