6533b861fe1ef96bd12c4cba
RESEARCH PRODUCT
Chemically driven phase separation in black lipid membranes and its coupling to membrane functions
J. SpinkeHelmut RingsdorfWolfgang KnollManfred SchmidtRainer BlankenburgJ. ZöllerStephan Förstersubject
StereochemistryChemistryPeripheral membrane proteinLipid microdomainMetals and AlloysSynthetic membraneBiological membraneSurfaces and InterfacesPolar membraneSurfaces Coatings and FilmsElectronic Optical and Magnetic MaterialsOrientations of Proteins in Membranes databaseMembraneMaterials ChemistryBiophysicsMembrane biophysicsdescription
Abstract We analysed the single-channel current fluctuations of gramicidin in bimolecular lipid membranes in order to demonstrate (i) the influence of protein binding to the lateral organisation of a mixed membrane, and (ii) how this couples to the function of the ionophore. Examples of phase separations induced by synthetic polyelectrolytes, as models for peripheral membrane proteins, and specific ligand-receptor interactions are presented and discussed in view of the important lateral order-function relationship in biomembranes.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1992-04-01 | Thin Solid Films |