6533b861fe1ef96bd12c4d36

RESEARCH PRODUCT

Neue chemotherapeutisch-aktive 4-trifluormethylpyrimidine

Angelika BurgerAlfred Kreutzberger

subject

DiketoneOrganic ChemistryCondensationHuman immunodeficiency virus (HIV)Biological activitymedicine.disease_causeBiochemistryInorganic Chemistrychemistry.chemical_compoundchemistrymedicineMethylguanidineEnvironmental ChemistryOrganic chemistryPhysical and Theoretical ChemistrySulfate

description

Abstract Condensation of N -(2-hydroxyethyl)- N -methylguanidine sulfate with various β-diketonesbearing 1,1,1-trifluoromethyl substituents leads to 2-[ N -(2-hydroxyethyl)-methylamino]-4-trifluoromethylpyrimidine derivatives. These compounds exhibit antimycotic, trichomonazide and anti-HIV properties.

yearjournalcountryeditionlanguage
1993-02-01Journal of Fluorine Chemistry
https://doi.org/10.1016/s0022-1139(00)80040-8