6533b861fe1ef96bd12c4d7e

RESEARCH PRODUCT

3,4,5,3’,5’-pentabromo-2-(2’-hydroxybenzoyl) pyrrole: a potential lead compound as anti Gram-positive and anti biofilm agent

Salvatore PetrusoDomenico SchillaciV. Sciortino

subject

Microbiology (medical)Gram-positive bacteriaTetrazolium SaltsMicrobial Sensitivity Testsmedicine.disease_causeGram-Positive BacteriaMicrobiologychemistry.chemical_compoundMinimum inhibitory concentrationStaphylococcus epidermidisDrug Resistance BacterialmedicineHumansPharmacology (medical)PyrrolesPyrrolebiologyAntimicrobici Staphylococci Anti-biofilmBiofilmAntimicrobici Staphylococci Anti-biofilmGeneral Medicinebiology.organism_classificationAnti-Bacterial AgentsHydrocarbons BrominatedThiazolesInfectious DiseaseschemistryStaphylococcus aureusBiofilmsGentian VioletLead compoundBacteria

description

The activity against Gram-positive bacteria of 3,4,5,3 ,5 -pentabromo-2-(2 -hydroxybenzoyl)pyrrole I, a synthetic anti-bacterial compound related to pyrrolomycins, was tested in vitro using seven reference bacterial strains and Staphylococcus epidermidis and Staphylococcus aureus preformed biofilms. Compound I was active against all strains tested, with minimum inhibitory concentration (MIC) values ranging from 0.002 to 0.097 mg/l and minimum bactericidal concentrations (MBCs) from 0.37 to 12.5 mg/l. Compound I was also active at low concentrations against preformed S. epidermidis and S. aureus biofilms.

yearjournalcountryeditionlanguage
2005-01-01
10.1016/j.ijantimicag.2004.11.014http://hdl.handle.net/10447/4871