6533b861fe1ef96bd12c4dca

RESEARCH PRODUCT

The effect of methacholine on noradrenaline release from the rabbit heart perfused with indometacin

H. FuderErich Muscholl

subject

Malemedicine.medical_specialtySympathetic Nervous SystemTime FactorsHeart VentriclesIndomethacinSympathetic nerveStimulationIn Vitro TechniquesFeedbackNorepinephrineIndometacinHeart RateInternal medicineMuscarinic acetylcholine receptormedicineAnimalsMethacholine CompoundsHeart AtriaPharmacologyChemistryMyocardiumRabbit heartHeartGeneral MedicineElectric StimulationStimulation ChemicalBlockadePerfusionEndocrinologyDepression ChemicalProstaglandinsFemaleMethacholineRabbitsPerfusionmedicine.drug

description

The experiments were undertaken in order to study the effect of inhibition of prostaglandin synthesis on the muscarinic inhibition of noradrenaline release evoked by sympathetic nerve stimulation. The right sympathetic nerves of the perfused rabbit heart were stimulated electrically. The noradrenaline output was enhanced after perfusion of the hearts with indometacin 3×10−5 M indicating blockade of the prostaglandin-mediated negative feedback control. Both in the presence and in the absence of indometacin methacholine 4×10−5 M decreased the noradrenaline output by a similar percentage. It is concluded that the muscarinic inhibition of noradrenaline release does not require the functional integrity of the prostaglandin-mediated feedback system.

yearjournalcountryeditionlanguage
1974-01-01Naunyn-Schmiedeberg's Archives of Pharmacology
https://doi.org/10.1007/bf00501148