MTHFR and VDR Polymorphisms Improve the Prognostic Value of MYCN Status on Overall Survival in Neuroblastoma Patients

6533b861fe1ef96bd12c4e72

RESEARCH PRODUCT

MTHFR and VDR Polymorphisms Improve the Prognostic Value of MYCN Status on Overall Survival in Neuroblastoma Patients

Pablo Gargallo Victoria Castel Jaime Font De Mora David Hervás Luis Sendra Vanessa Segura Miguel A. Sanz Pablo Berlanga Adela Cañete Gladys Olivera Salvador F. Aliño Salvador F. Aliño María José Herrero Yania Yáñez

subject

Oncology medicine.medical_specialty SNP Single-nucleotide polymorphism Logistic regression survival Calcitriol receptor Article Catalysis lcsh:Chemistry Inorganic Chemistry neuroblastoma Internal medicine Neuroblastoma medicine SNP Physical and Theoretical Chemistry lcsh:QH301-705.5 Molecular Biology Spectroscopy pharmacogenetics biology business.industry Organic Chemistry toxicity General Medicine medicine.disease Computer Science Applications lcsh:Biology (General)lcsh:QD1-999 Methylenetetrahydrofolate reductase Cohort biology.protein business Pharmacogenetics

description

Single nucleotide polymorphisms (SNPs) in Pharmacogenetics can play an important role in the outcomes of the chemotherapy treatment in Neuroblastoma, helping doctors maximize efficacy and minimize toxicity. Employing AgenaBioscience MassArray, 96 SNPs were genotyped in 95 patients looking for associations of SNP with response to induction therapy (RIT) and grade 3&ndash

year	journal	country	edition	language
2020-04-01	International Journal of Molecular Sciences

https://doi.org/10.3390/ijms21082714

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