6533b861fe1ef96bd12c4eb3

RESEARCH PRODUCT

Mycotoxin Identification and In Silico Toxicity Assessment Prediction in Atlantic Salmon

Noelia PallarésFrancisco J. BarbaJosefa TolosaEmilia Ferrer

subject

Spectrometry Mass Electrospray IonizationAtlantic salmonin silico predictionIn silicoSalmo salarPharmaceutical ScienceFood ContaminationAquacultureRisk Assessment01 natural sciencesArticleOphiobolinschemistry.chemical_compound0404 agricultural biotechnologymycotoxinsDrug DiscoveryAnimalsliquid chromatographyComputer SimulationFood scienceSalmoMycotoxinlcsh:QH301-705.5Pharmacology Toxicology and Pharmaceutics (miscellaneous)Chromatography High Pressure Liquidbiology010401 analytical chemistry04 agricultural and veterinary sciencestime of flight mass spectrometrybiology.organism_classificationAnimal Feed040401 food scienceToxicokinetics0104 chemical sciencesSeafoodlcsh:Biology (General)chemistryMycotoxin identificationToxicityFish <Actinopterygii>Potential toxicity

description

The present study aimed to identify mycotoxins in edible tissues of Atlantic salmon (Salmo salar) using liquid chromatography coupled to hybrid quadrupole time-of-flight mass spectrometry (LC-Q-TOF-MS). After using a non-targeted screening approach and a home-made spectral library, 233 mycotoxins were analyzed. Moreover, the occurrence of mycotoxins in fish filets was evaluated, and their potential toxicity was predicted by in silico methods. According to the obtained results, forty mycotoxins were identified in analyzed salmon samples, the predominant mycotoxins being enniatins (also rugulosin and 17 ophiobolins), commonly found in cereals and their by-products. Thus, mycotoxin carry-over can occur from feed to organs and edible tissues of cultivated fish. Moreover, the toxicity of detected mycotoxins was predicted by the in silico webserver ProTox-II, highlighting that special attention must be paid to some less reported mycotoxins due to their toxic predicted properties.

yearjournalcountryeditionlanguage
2020-12-10Marine Drugs
https://doi.org/10.3390/md18120629