6533b861fe1ef96bd12c4fcb
RESEARCH PRODUCT
Mandelamide-zinc-catalyzed enantioselective alkyne addition to heteroaromatic aldehydes.
Gonzalo BlayIsabel FernándezJosé R. PedroAlicia Marco‐aleixandresubject
chemistry.chemical_classificationArylOrganic ChemistryEnantioselective synthesischemistry.chemical_elementAlkyneGeneral MedicineZincAldehydeChemical synthesisCatalysischemistry.chemical_compoundchemistryHeterocyclic compoundReagentOrganic chemistryEnantiomerMandelamidedescription
The (S,S)-mandelamide III catalyzes the additions of both aryl- and alkylalkynylzinc reagents to heteroaromatic aldehydes with good yields and enantioselectivities up to 92%. This catalyst is easily prepared in a one-step procedure, and both enantiomers are available. Unlike most other described methods, using this catalyst does not require the addition of Ti(O(i)Pr)4.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2006-08-12 | The Journal of organic chemistry |