6533b861fe1ef96bd12c5643
RESEARCH PRODUCT
Gastroesophageal Reflux and Bleeding Esophageal Varices
Norman D. GraceNorman D. GraceVolker F. EckardtVolker F. Eckardtsubject
medicine.medical_specialtyCirrhosisHepatologybusiness.industryIncidence (epidemiology)digestive oral and skin physiologyGastroenterologyRefluxVariceal hemorrhagemedicine.diseaseGastroenterologydigestive system diseasesInternal medicineHealthy controlmedicineBleeding esophageal varicesEsophageal sphincterIn patientbusinessdescription
The incidence of gastroesophageal reflux was evaluated with the use of a pH probe in 12 patients with cirrhosis and recent variceal hemorrhage and in 15 healthy control subjects. Short episodes of reflux occurred in 42% of the patients and in 47% of the controls. During an observation period of 1 hr, the cumulative duration of reflux was similar in patients (2.5 ± 1.3 min) and controls (3.1 ± 1.4 min). Mean lower esophageal sphincter pressures were normal in both groups but did not show a significant correlation with the duration of reflux. These data support previous observations that gastroesophageal reflux does not appear to be a contributing factor in the development of variceal hemorrhage.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1979-01-01 | Gastroenterology |