6533b861fe1ef96bd12c56b1
RESEARCH PRODUCT
false
subject
0301 basic medicinegenetic structuresBioinformaticsmedicine.disease_causeCatalysisInorganic ChemistryPathogenesis03 medical and health sciences0302 clinical medicineAge relatedMedicinePhysical and Theoretical ChemistryOcular diseaseMolecular BiologySpectroscopychemistry.chemical_classificationReactive oxygen speciesbusiness.industryOrganic ChemistryGeneral MedicineMacular degenerationmedicine.diseaseeye diseasesPathophysiologyComputer Science Applications030104 developmental biologychemistry030221 ophthalmology & optometrysense organsVascular functionbusinessOxidative stressdescription
Age-related macular degeneration (AMD) is a common irreversible ocular disease characterized by vision impairment among older people. Many risk factors are related to AMD and interact with each other in its pathogenesis. Notably, oxidative stress and choroidal vascular dysfunction were suggested to be critically involved in AMD pathogenesis. In this review, we give an overview on the factors contributing to the pathophysiology of this multifactorial disease and discuss the role of reactive oxygen species and vascular function in more detail. Moreover, we give an overview on therapeutic strategies for patients suffering from AMD.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2021-01-28 | International Journal of Molecular Sciences |