6533b861fe1ef96bd12c5705
RESEARCH PRODUCT
Selective loss of regulatory T cells in thymomas
Alexander MarxO. ElertChristof BurekPeter RieckmannAndreas RosenwaldWilfred NixHans Konrad Müller-hermelinkThomas KerkauPärt PetersonAstrid MurumägiNiklas BeyersdorfVera HummelBerthold SchalkePhilipp StröbelReinhard KieferNiko Sillanpääsubject
Programmed cell deathThymomabusiness.industryEffectorCellular differentiationchemical and pharmacologic phenomenaT lymphocytemedicine.diseasePhenotypeClonal deletionMyasthenia gravissurgical procedures operativeNeurologyhemic and lymphatic diseasesImmunologyCancer researchMedicineNeurology (clinical)businessneoplasmsdescription
Myasthenia gravis (MG) is the prime autoimmune manifestation of thymomas. We investigated the generation of T cells with a regulatory phenotype (T(R)) in thymomas with and without associated MG. In patients with MG(+) thymomas, maturation and export of T(R) cells but not of other T-cell subsets was significantly reduced. We conclude that imbalance between effector and regulatory T cells in thymomas may be involved in modulation of onset and/or severity of MG.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2004-11-23 | Annals of Neurology |