6533b861fe1ef96bd12c596f

RESEARCH PRODUCT

Role of Natural Cross Linkers in Resin–Dentin Bond Durability: A Systematic Review and Meta-Analysis

Lavanya AnumulaSindhu RameshVenkata Suneel Kumar KolaparthiRichard KirubakaranMohmed Isaqali KarobariSuraj AroraAhmed A. SalehOmir AldowahPietro MessinaAlessandro Scardina

subject

matrix metalloproteinase inhibitorsmatrix metalloproteinase; matrix metalloproteinase inhibitors; plant extract; Grape seed extract; flavonoidsmatrix metalloproteinaseflavonoidsplant extractGeneral Materials ScienceGrape seed extract

description

Background: The role of endogenous Matrix Metallo Proteinases in resin dentin bond deterioration over time has been well documented. The present study aimed to systematically review the literature; in vitro and ex vivo studies that assessed the outcomes of natural cross-linkers for immediate and long-term tensile bond strength were included. Methods: The manuscript search was carried out in six electronic databases—PubMed/MEDLINE, LILACS, SciELO, Cochrane, Web of Science and DOAJ, without publication year limits. Only manuscripts in English (including the translated articles) were selected, and the last search was performed in December 2020. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement was followed. Results: From the 128 potentially eligible studies, 48 full-text articles were assessed for eligibility. After eligibility assessment and exclusions, 14 studies were considered for systematic review and seven studies for meta-analysis. Amongst the selected studies for meta-analysis, three had a medium and four had a low risk of bias. Conclusions: It was evidenced by the available data that Proanthocyanidin is the most efficient natural cross-linker to date, in preserving the bond strength even after ageing.

yearjournalcountryeditionlanguage
2022-08-17
10.3390/ma15165650https://hdl.handle.net/10447/577844