6533b861fe1ef96bd12c59ac
RESEARCH PRODUCT
A standard calculation methodology for human doubly labeled water studies.
Stefan G J A CampsRoberto A RabinovichJennifer RoodRichard CooperLene Frost AndersenGuy PlasquiEllen E. BlaakAlbertine J. SchuitStéphane BlancStéphane BlancMarije B. HoosPhilip N. AinslieAnders SjödinKlaas R. WesterterpHerman PontzerBrian M. WoodBrian M. WoodCara B. EbbelingDavid S. LudwigAnine Christine MedinAnine Christine MedinIssaad BaddouElena S. F. BermanJacob Plange-rhuleMisaka KimuraKirsi H. PietiläinenGiulio ValentiPascal BovetEstelle V. LambertJamie A. CooperUlf EkelundHiroyuki SagayamaYosuke YamadaSumei HuSamuel S. UrlacherEdward L. MelansonEdward L. MelansonRobert OjiamboKweku Bedu-addoWilliam E. KrausAlberto G. BonomiRoss L. PrenticeNoorjehan JoonasErwin P. MeijerSonja EntringerSonja EntringerWilliam R. LeonardSusan B. RacetteJames C MorehenJames C MorehenMarian L. NeuhouserGeorge S. WilsonEric RavussinRebecca M. ReynoldsJohn R. SpeakmanMaciej S. BuchowskiJack A. YanovskiRobert F. KushnerAmy LukeAsmaa El HamdouchiNancy F. ButteLenore ArabMichael GurvenKitty P. KempenNader LessanYannis P. PitsiladisJames P. MortonAlexia J. Murphy-alfordLara R. DugasPeter T. KatzmarzykSai Krupa DasXueying ZhangXueying ZhangSeth A. CreasyJonathan C. K. WellsAnnemiek M. C. P. JoosenDale A. SchoellerCatherine HamblyTerrence ForresterWilliam W. WongCornelia U LoechlBarry W. FudgeGraeme L. CloseEric SticeTheresa A. NicklasLudo M. Van EttenEdgar A. Van MilLiam AndersonAnnelies H. C. GorisCarlijn V. C. BoutenSusan B. RobertsDavid A. RaichlenTsukasa YoshidaCorby K. Martinsubject
IndirectFuture studiesBODY-WATER030309 nutrition & dietetics[SDV]Life Sciences [q-bio]Body waterINFANTS030209 endocrinology & metabolismDoubly labeled watertotal energy expenditureCarbon dioxide productionCalorimetryOxygen IsotopesCalorimetryArticleGeneral Biochemistry Genetics and Molecular BiologyRC120003 medical and health sciences0302 clinical medicineTotal energy expendituredoubly labeled water; free-living; total energy expenditure; validationStatisticsINDIRECT CALORIMETRYRange (statistics)O-18HumansObesity(H2O)-H-2-O-18 METHODCARBON-DIOXIDE PRODUCTIONComputingMilieux_MISCELLANEOUSMathematicsCO2 PRODUCTIONH-2validation0303 health sciencesfree-livingDILUTION SPACE RATIOENERGY-EXPENDITUREWaterCalorimetry IndirectDeuterium6. Clean waterdoubly labeled waterDilutionIAEA DLW database groupBody Composition1182 Biochemistry cell and molecular biologyEnergy Metabolismdescription
Summary The doubly labeled water (DLW) method measures total energy expenditure (TEE) in free-living subjects. Several equations are used to convert isotopic data into TEE. Using the International Atomic Energy Agency (IAEA) DLW database (5,756 measurements of adults and children), we show considerable variability is introduced by different equations. The estimated rCO2 is sensitive to the dilution space ratio (DSR) of the two isotopes. Based on performance in validation studies, we propose a new equation based on a new estimate of the mean DSR. The DSR is lower at low body masses (<10 kg). Using data for 1,021 babies and infants, we show that the DSR varies non-linearly with body mass between 0 and 10 kg. Using this relationship to predict DSR from weight provides an equation for rCO2 over this size range that agrees well with indirect calorimetry (average difference 0.64%; SD = 12.2%). We propose adoption of these equations in future studies.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2021-02-16 |