6533b861fe1ef96bd12c59e2
RESEARCH PRODUCT
Increased percentages of calprotectin and TNF-Α double-positive monocytes in the acute phase of Kawasaki disease
Giuliana GugginoMahavir SinghEiji OhtsuFrancesco DieliGuido SireciSalvatore AccomandoGabriele SimoniniRolando CimazIlaria PagniniTomisaku Kawasakisubject
Pediatricsmedicine.medical_specialtylcsh:Diseases of the musculoskeletal systemDouble negativeInflammationTNF alfa CalprotectinImmune systemSettore MED/38 - Pediatria Generale E SpecialisticaRheumatologyInternal medicineImmunology and AllergyMedicineSecretionPediatrics Perinatology and Child HealthKawasaki Diseasebusiness.industrylcsh:RJ1-570lcsh:Pediatricsmedicine.diseaseRheumatologyPediatrics Perinatology and Child HealthImmunologyOral PresentationKawasaki diseaselcsh:RC925-935Calprotectinmedicine.symptombusinessVasculitisdescription
Background The acute phase of KD is characterized by a deficiency of suppressor T cells, marked activation of the immune system and increased secretion of cytokines by immune effector cells. Moreover, it has been shown that myeloid-related protein (MRP-8 and MRP-14) and S100proteins, the major calcium-binding proteins secreted by activated neutrophils and monocytes, contribute to cause inflammation in acute lesions of KD, and indeed one of the more common hematological alteration in KD is the increase of peripheral blood monocytes. Calprotectin, one of the major calcium-binding proteins, can lead to direct and indirect effects that result not only in inflammation but also in modification of microvascular wall in acute vasculitis syndromes.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2011-09-01 | Pediatric Rheumatology Online Journal |