6533b861fe1ef96bd12c59f0

RESEARCH PRODUCT

Fungal Infections of the Central Nervous System in Children.

Thomas J. WalshVidmantas PetraitisRuta PetraitieneMatthew W. MccarthyDarius KalasauskasDarius Kalasauskas

subject

0301 basic medicineCentral Nervous Systemmedicine.medical_specialtyAntifungal Agents030106 microbiologyCentral nervous systemAspergillosisHistoplasmosisBlastomycosis03 medical and health sciencesCentral Nervous System Fungal InfectionsEpidemiologymedicineAspergillosisHumansMucormycosisIntensive care medicineChildHistoplasmosisCoccidioidomycosisbusiness.industryMortality rateMucormycosisCandidiasisFungiGeneral MedicineCryptococcosismedicine.diseaseInfectious Diseasesmedicine.anatomical_structurePediatrics Perinatology and Child HealthCryptococcosisbusinessBlastomycosis

description

Although uncommon in children, fungal infections of the central nervous system can be devastating and difficult to treat. A better understanding of basic mycologic, immunologic, and pharmacologic processes has led to important advances in the diagnosis and management of these diseases, but their mortality rates remain unacceptably high. In this focused review, we examine the epidemiology and clinical features of the most common fungal pathogens of the central nervous system in children and explore recent advances in diagnosis and antifungal therapy.

yearjournalcountryeditionlanguage
2017-05-18Journal of the Pediatric Infectious Diseases Society
10.1093/jpids/pix059https://pubmed.ncbi.nlm.nih.gov/28903523