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RESEARCH PRODUCT
Effects of Polycyclic Aromatic Hydrocarbons on Lung Function in Children with Asthma: A Mediation Analysis.
Giovanna CilluffoGiuliana FerranteNicola MurgiaRosanna ManciniSimona PichiniGiuseppe CuffariVittoria GiudiceNicolò TironeVelia MaliziaLaura MontalbanoSalvatore FasolaRoberta PacificiGiovanni ViegiStefania La Gruttasubject
Mediation AnalysisHealth Toxicology and MutagenesisPublic Health Environmental and Occupational HealthRAmbientalelung functionpolycyclic aromatic hydrocarbons lung function children asthma mediation analysisAsthmapolycyclic aromatic hydrocarbons; lung function; children; asthma; mediation analysischildrenMedicineHumansProspective StudiesPolycyclic Aromatic HydrocarbonsChildAsthma Children Lung function Mediation analysis Polycyclic aromatic hydrocarbons Child Humans Lung Mediation Analysis Prospective Studies Asthma Polycyclic Aromatic Hydrocarbonsasthma children lung function mediation analysis polycyclic aromatic hydrocarbonsLungdescription
Studies investigating the association between urinary Polycyclic Aromatic Hydrocarbons (PAHs) and asthma in children provided inhomogeneous results. We aimed to use Mediation Analysis to discover whether a link between urinary PAHs and lung function exists and if it might be ascribed to a direct or a symptom-mediated (indirect) effect in children with asthma. This single-center prospective study was conducted in Palermo, Italy, between March and July 2017 and involved 50 children with persistent mild-moderate asthma, aged 6–11 years. At each time visit (day 0, 30, 60, and 90), physical examination, spirometry, and urine collection for detection of urinary cotinine and PAHs were performed. A symptom score was computed. The sum of individually calculated molar mass of nine PAH metabolites (ΣPAH), naphthalene metabolites (ΣPAHn) and phenanthrene metabolites (ΣPAHp) were calculated. Three children withdrew from the study due to technical problems (n = 1) and adverse events (n = 2). PAHs indirect effects on FEV1 (ΣPAH: −0.011, p = 0.04; ΣPAHn: −0.011, p = 0.04; ΣPAHp: −0.012, p p = 0.02; ΣPAHn: −0.0126, p = 0.02; ΣPAHp: −0.013, p < 0.001) were statistically significant. In conclusion, PAHs exposures have significant indirect (symptom-mediated) effects on lung function, emphasizing the role of PAHs-induced respiratory morbidity in decreasing lung function in children with asthma.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2022-02-05 | International journal of environmental research and public health |