N-BiPAP vs n-CPAP in term neonate with respiratory distress syndrome

6533b861fe1ef96bd12c5a71

RESEARCH PRODUCT

N-BiPAP vs n-CPAP in term neonate with respiratory distress syndrome

Raffaele Falsaperla Marco Andrea Nicola Saporito Giovanni Corsello Carla Cimino Eloisa Gitto Piero Pavone Riccardo Lubrano Laura Mauceri Giovanna Vitaliti

subject

Male Term infants Respiratory distress syndrome medicine.medical_treatment Continuous positive airway pressure Vital signs Biphasic positive airway pressure NO Biphasic Positive Airway Pressure Positive-Pressure Respiration 03 medical and health sciences 0302 clinical medicine 030225 pediatrics medicine Humans Biphasic positive airway pressure; Continuous positive airway pressure; Non-invasive ventilation; Respiratory distress syndrome; Term infants;Continuous positive airway pressure Respiratory system Full Term Respiratory Distress Syndrome Newborn Noninvasive Ventilation Respiratory distress business.industry Infant Newborn Obstetrics and Gynecology respiratory system medicine.disease Biphasic positive airway pressure; Continuous positive airway pressure; Non-invasive ventilation; Respiratory distress syndrome; Term infants Term infants.Pneumothorax Anesthesia Pediatrics Perinatology and Child Health Non-invasive ventilation Breathing Female business 030217 neurology & neurosurgery

description

Abstract Background Non-invasive respiratory ventilation has greatly improved the evolution of respiratory distress in neonates, especially for preterm infants, but few studies have investigated the use of non-invasive ventilation (NIV) in term infants. It is useful for neonatologists and nurses to identify the optimal ventilation strategy in terms of effectiveness for this group of newborns. The aim of our study was to investigate what type of respiratory support between nasal Continuous Positive Airway Pressure (nCPAP) or nasal Biphasic Positive Airway Pressure (nBiPAP) is more effective in term neonates with RDS. Methods Our study was a retrospective observational study of 78 full term neonates who were admitted to the NICU at S. Bambino Hospital from December 2015 to December 2016 for respiratory distress at birth. All patients underwent non-invasive ventilation by nCPAP or nBiPAP were included. Oxygen saturations and vital signs were monitored continuously. We evaluated blood gas analysis parameters before treatment and after 1 h of ventilation. Results During the study period, there were 78 full term newborns admitted in our NICU for neonatal distress who were treated with nCPAP ore nBIPAP ventilation. In nBiPAP patients, we noticed a statistically significant reduction in PaCO2 levels and FiO2 requirement with respect to nCPAP patients, after 1 h of ventilation with a simultaneous significant increase of pH and PaO2 levels. There was no difference in the length of NIV and hospital stay. Among nCPAP patients, two were then intubated and one developed a pneumothorax. Conclusion The results of our study showed that an early BiPAP ventilation on RDS is the more efficient NIV because it improves CO2 removal and reduces FiO2 requirement in comparison to nCPAP. Future studies can clarify if early BiPAP ventilation on RDS is the more efficient of NIV.

year	journal	country	edition	language
2020-01-01	Early Human Development

https://doi.org/10.1016/j.earlhumdev.2020.104965