Izmaiņas augsta un vidēja riska gēnos gados jauniem melanomas pacientiem

6533b862fe1ef96bd12c5cb2

RESEARCH PRODUCT

Izmaiņas augsta un vidēja riska gēnos gados jauniem melanomas pacientiem

subject

melanoma augsta riska gēni Bioloģija mutācijas vidēja riska gēni polimorfismi

description

Melanoma ir ļaundabīgs ādas audzējs, kas attīstās vides un gēnu mijiedarbības rezultātā. Bakalaura darba mērķis bija izvērtēt izmaiņas augsta un vidēja riska gēnos melanomas pacientiem ar vairākiem primāriem audzējiem un gados jauniem (līdz 40 gadu vecumam) melanomas pacientiem Latvijā. Analīzē tika iekļauti seši pacienti ar vairākām primārām melanomām un 67 gados jauni melanomas pacienti. Tika izanalizēti pieci augsta (CDKN2A, CDK4, BAP1, POT1, TERT) un divi vidēja (MITF, MC1R) melanomas riska gēni. Atrastas trīs dažādas izmaiņas POT1 gēnā, no kurām viena ir jauna līdz šim neaprakstīta izmaiņa, viens rets MITF, divi CDKN2A un 8 dažādi MC1R gēnu polimorfismi. Izmaiņas BAP1, POT1 un CDK4 gēnos atrastas netika. Darbs izstrādāts Latvijas Biomedicīnas pētījumu un studiju centrā laika posmā no 2015. gada septembra līdz 2016. gada maijam.

year	journal	country	edition	language
2016-01-01

https://dspace.lu.lv/dspace/handle/7/32187

PEPhysical Sciences and Engineering
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SHSocial Sciences and Humanities
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