6533b862fe1ef96bd12c5e8b

RESEARCH PRODUCT

HUMAN HERPESVIRUS 8 SEROPREVALENCE AMONG INTERNATIONALLY ADOPTED CHILDREN COMING FROM EASTERN EUROPE

E. VivianoVitale FrancescoA. M. PernaF. CataldoA. FirenzeN. Romano

subject

MaleInternationalityAdopted children Eastern Europe Human Herpes Virus 8 Seroepidemiology .AdolescentInfantHIV InfectionsHerpesviridae InfectionsHepatitis AAntibodies ViralHepatitis BSettore MED/42 - Igiene Generale E ApplicataHepatitis CSeroepidemiologic StudiesChild PreschoolAdoptionHerpesvirus 8 HumanHumansFemaleEurope EasternChild

description

The seroprevalence of Human Herpes Virus 8 (HHV8) and its transmission pattern were assessed testing serum samples of 120 internationally adopted children (aged 1-15 years) coming from Eastern Europe. Determinations of IgG antibodies against both latent and lytic HHV-8 antigens were performed by indirect immunofluorescence assay. Antibodies were detected only for lytic antigen of the virus in 12.5% of children with a seroprevalence significatively higher (19.6%) in young children (age 1-6). No correlation was observed between HHV8 seropositivity and serological markers for hepatitis A, B and C viruses and Human Immunodeficiency virus. In conclusion, our findings suggest that HHV8 infection is widespread in some populations from the East Europe, and that person to person contacts among children could be considered the predominant mode of HHV8 transmission in younger age.

yearjournalcountryeditionlanguage
2009-04-23
http://hdl.handle.net/10447/39315