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RESEARCH PRODUCT
Sorafenib in Mice – A Pharmacokinetic Study
Ra AbbiatiD. MancaGennara CavallaroEmanuela Fabiola Craparosubject
lcsh:Computer engineering. Computer hardwareSettore CHIM/09 - Farmaceutico Tecnologico Applicativosorafenib Pharmacokinetic Studylcsh:TP155-156lcsh:TK7885-7895lcsh:Chemical engineeringdescription
Pharmacokinetic models are applied to determine the drug distribution in the organism with respect to a given administration. Models based on body anatomy and physiology can provide an accurate description of drug concentrations reached in specific organs and tissues of mammals. This article proposes a model based on mammalian anatomy and physiology to predict the biodistribution in mice of sorafenib, an anti-cancer drug, with specific attention to the concentration reached in the liver, as that is the action site in case of hepatocellular carcinoma treatment. The model reveals a close correspondence respect to experimental concentration data in the organism and also assesses with good fidelity the enterohepatic circulation, a phenomenon occurring at the liver-intestine level and that strongly characterizes sorafenib distribution.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2015-05-01 | Chemical Engineering Transactions |