0000000001155803
AUTHOR
D. Manca
Sorafenib in Mice – A Pharmacokinetic Study
Pharmacokinetic models are applied to determine the drug distribution in the organism with respect to a given administration. Models based on body anatomy and physiology can provide an accurate description of drug concentrations reached in specific organs and tissues of mammals. This article proposes a model based on mammalian anatomy and physiology to predict the biodistribution in mice of sorafenib, an anti-cancer drug, with specific attention to the concentration reached in the liver, as that is the action site in case of hepatocellular carcinoma treatment. The model reveals a close correspondence respect to experimental concentration data in the organism and also assesses with good fide…
Hydro-Mechanical Behaviour of a Sand-Bentonite Mixture for the Confinement of Nuclear Wastes
The established concept for the protection of the biosphere from high-level nuclear wastes consists in the use of multi-barrier systems in deep geological repository, for which clayey geomaterials are key elements. Bentonite-based materials are selected as buffer and backfilling materials. Once in place, the barriers will be subjected to a series of severe loadings, including strong variations of suction (i.e. wetting and drying cycles). The paper presents selected results from a large ongoing research work to investigate the behaviour of bentonite-based materials in the context of nuclear waste disposal. In particular, the paper focuses on the response of a Sand/Bentonite mixture under dif…