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RESEARCH PRODUCT
13C NMR studies of dianions of unsaturated carboxylic acids
Ramon MestresA. TortajadaMajosé AurellSalvador GilMargarita Parrasubject
DeprotonationchemistryOrganic ChemistryDrug DiscoveryElectrophileInorganic chemistrychemistry.chemical_elementLithiumCarbon-13 NMRResonance (chemistry)BiochemistryMedicinal chemistrySpectral linedescription
Abstract 13C NMR Spectra of the dianions Li2-n resulting from double deprotonation of unsaturated carboxylic acids 1 to 6 by lithium dialkylamides, are examined. Higher field resonance for C2 than for C4 atoms are observed, which reveal higher elctron density at C2 than at C4, in agreement with the kinetic α-regioselectivity exhibited by these dianions on reaction with electrophiles.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1994-04-01 | Tetrahedron |