6533b862fe1ef96bd12c6298
RESEARCH PRODUCT
Cutaneous Leishmania infection: progress in pathogenesis research and experimental therapy.
Esther Von Stebutsubject
biologyLeishmaniasis CutaneousLeishmaniasisDermatologyDendritic cellmedicine.diseaseLeishmaniabiology.organism_classificationBiochemistryVirologyImmunityImmunologymedicineCytotoxic T cellAnimalsHumansLeishmania majorAntigen-presenting cellAmastigoteMolecular BiologyLeishmania majorSkindescription
Studies in murine experimental Leishmania major infection have helped to understand the requirements for efficient development of T helper (Th)1/cytotoxic T (Tc)1-mediated protection against the parasite. As such they have revealed that Fc gamma receptor (Fc gamma R)I and Fc gamma RIII-mediated uptake of L. major amastigotes by dendritic cells (DC) is an important prerequisite for Th1 development. In addition, DC-derived cytokines contribute to adequate T-cell education. DC-based vaccines may thus provide an important tool for both the development of a prophylactic vaccine against leishmaniasis and - together with leishmanicidal drugs - for eliciting immune-deviating functions towards protective immunity in non-healing leishmaniasis. This review highlights recent advances in the understanding of the role of DC for the induction of Th1/Tc1-predominant immunity against L. major and how this knowledge may translate into clinical approaches.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2007-04-01 | Experimental dermatology |