Squaramide-Catalyzed Enantioselective Michael Addition of Pyrazol-3- ones to ortho-Quinone Methides

6533b862fe1ef96bd12c6300

RESEARCH PRODUCT

Squaramide-Catalyzed Enantioselective Michael Addition of Pyrazol-3- ones to ortho-Quinone Methides

Carlos Vila Gonzalo Blay José R. Pedro Laura Carceller-ferrer

subject

Catàlisi Chemistry Organic Chemistry Michael reaction Enantioselective synthesis Squaramide Biochemistry Medicinal chemistry Química orgànica Quinone Catalysis

description

A bifunctional squaramide catalyzed the enantioselective Michael addition of pyrazol-3- ones to ortho-quinone methides, generated in situ from 2-(1-tosylalkyl)phenols is presented. The corresponding chiral pyrazolones are obtained with good to excellent yields (27-98%) and enantiomeric excess (14-99% ee).

year	journal	country	edition	language
2020-11-29

10.2174/1876402911666190806105543 https://hdl.handle.net/10550/84626

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