6533b862fe1ef96bd12c6354

RESEARCH PRODUCT

When GLP-1 hits the liver: a novel approach for insulin resistance and NASH

Yong Ook KimDetlef Schuppan

subject

Malemedicine.medical_specialtyCirrhosisPhysiologydigestive systemGastroenterologyGlucagon-Like Peptide-1 ReceptorSimple steatosisInsulin resistanceNon-alcoholic Fatty Liver DiseaseFibrosisPhysiology (medical)Internal medicineNonalcoholic fatty liver diseaseReceptors GlucagonAnimalsMedicineHepatologybusiness.industryDisease progressionGastroenterologynutritional and metabolic diseasesmedicine.diseasedigestive system diseasesSevere inflammationFatty LiverSteatohepatitisPeptidesbusiness

description

nonalcoholic fatty liver disease (NAFLD) encompasses a spectrum ranging from simple steatosis to steatohepatitis (NASH), increasing fibrosis and eventually, cirrhosis ([22][1]). Importantly, NASH accompanied by fibrosis and severe inflammation is the most relevant predictor for disease progression

https://doi.org/10.1152/ajpgi.00078.2012