6533b862fe1ef96bd12c6419

RESEARCH PRODUCT

The role of apoptosis versus oncotic necrosis in liver injury: Facts or faith?

Henning Schulze-bergkamenMarcus SchuchmannB. FleischerPeter R. Galle

subject

Liver injurymedicine.medical_specialtyProgrammed cell deathNecrosisHepatologyLiver DiseasesApoptosisBiologyHepatologymedicine.diseaseBioinformaticsNecrosisFulminant hepatic failureLiverApoptosisInternal medicineHepatocellular carcinomaImmunologyDeath-inducing signaling complexmedicineAnimalsHumansmedicine.symptom

description

A tightly controlled balance between cell division and cell death is a basic feature for the development and maintenance of liver homeostasis. Disturbances of this balance contribute to liver diseases: too much cell death can cause liver injury, too little cell death is a prerequisite for the development of hepatocellular carcinoma. Thus, a stringent control of the equilibrium of life and death in the liver is necessary. During the last decade most research activities in hepatology dealing with liver injury focussed on the evaluation of apoptosis pathways. Therefore, our understanding of the mechanisms of apoptosis has made profound progress. Programmed cell death (PCD) in the liver enables the

yearjournalcountryeditionlanguage
2006-05-01Journal of Hepatology
https://doi.org/10.1016/j.jhep.2006.02.004