6533b862fe1ef96bd12c64ab
RESEARCH PRODUCT
Sicilian centenarian offspring are more resistant to immune ageing
Graziella RubinoGraziella RubinoMatteo BulatiAnna AielloFrancesco GervasiStefano AprileCaterina Maria GambinoGiulia AccardiCalogero Carusosubject
MaleAgingOffspringImmunosenescenceLongevityBiology03 medical and health sciences0302 clinical medicineImmunophenotypingImmune systemT-Lymphocyte SubsetsHumans030212 general & internal medicineCentenarianFlow cytometrySicilyAgedAged 80 and overInflammationSettore MED/04 - Patologia GeneraleImmunity CellularCase-control studyImmunosenescenceImmune senescenceMiddle AgedAgeingAgeingCase-Control StudiesCohortImmunologyAdult ChildrenFemaleCentenarianGeriatrics and Gerontology030217 neurology & neurosurgerydescription
Background: Immunosenescence constitutes a major indirect cause of morbidity and mortality in the elderly. Previous analysis of immune signatures in a cohort of centenarian offspring showed an intermediate immunophenotype between age-matched and younger controls. Aims: To confirm and extend the previous studies performing further phenotypical analysis in centenarian offspring and controls. Methods: Analysis of Treg cells, γδ T cells, mucosal-associated invariant T cells, and senescent immune T cells was performed in centenarian offspring and controls. Results: We report significant differences between elderly and centenarian offspring in most of the studied subsets, showing that centenarian offspring subsets present an intermediate phenotyping between elderly and younger people. Conclusion: The whole present data confirm and extend the previous results showing that centenarian offspring retain more youthful immunological parameters and that the exhaustion of the immune system is less evident than in elderly without centenarian parents, though further investigations are warranted.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2018-03-28 |