Competitive binding of Rab21 and p120RasGAP to integrins regulates receptor traffic and migration

6533b862fe1ef96bd12c64f2

RESEARCH PRODUCT

Competitive binding of Rab21 and p120RasGAP to integrins regulates receptor traffic and migration

Stefan Veltel Johanna Ivaska Johanna Ivaska Eleanor T. Coffey Varpu Marjomäki Anja Mai Anja Mai Artur Padzik Teijo Pellinen

subject

Cytoplasm Integrins Endosome Endocytic cycle Integrin Vesicular Transport Proteins Endosomes CD49c Binding Competitive Models Biological Article Collagen receptor 03 medical and health sciences Mice 0302 clinical medicine SDG 3 - Good Health and Well-being Cell Movement Cell Line Tumor Animals Humans Research Articles 030304 developmental biology 0303 health sciences biology Cell Membrane p120 GTPase Activating Protein Cell Biology Cell biology Protein Structure Tertiary Integrin alpha M rab GTP-Binding Proteins 030220 oncology & carcinogenesis biology.protein /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being Integrin beta 6 Rab Protein Binding

description

P120RasGAP competes with Rab21 for binding to the cytoplasmic domain of integrin α-subunits, thereby promoting receptor escape from early endosomes and recycling to the plasma membrane.

year	journal	country	edition	language
2011-07-18

10.1083/jcb.201012126 https://cris.vtt.fi/en/publications/16af4eea-519f-4ac8-8907-b0b8582802ab

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