6533b862fe1ef96bd12c6b8e

RESEARCH PRODUCT

24. Aminooxyacetate, an inhibitor of H2S production, potentiates lindane-induced convulsions in rats

subject

description

Purpose: H 2 S is a gaseous molecule recently recognized as endogenously produced neurotransmitter with different, still not well known, physiological and pathological roles. Cystathionine- β -synthase (CBS) is a major enzyme responsible for H 2 S production in the brain. The aim of this study was to investigate the effects of aminooxyacetate, potent CBS inhibitor, on convulsions induced by lindane in rats. Methods: Adult male Wistar albino rats were intraperitoneally (i.p.) treated with lindane 4 mg/kg and observed for convulsive behavioral manifestations during next 30 min. Aminooxyacetate (0.25 mmol/kg) or saline were injected 30 min prior to lindane administration. Seizure behavior was assessed by seizure incidence, latency time to first seizure onset and its severity assessed by descriptive scale with 4 grades. Results: Seizure incidence was higher in rats treated with aminooxyacetate prior to lindane, but the difference were not statistically significant comparing with those treated only with lindane. However, administration of aminooxyacetate significantly decreased the latency time to first seizure and significantly augmented severity of lindane-induced seizures. Conclusion: These results showed that aminooxyacetate, an inhibitor of H 2 S production, potentiated convulsive activity of lindane in rats.