6533b862fe1ef96bd12c6ba0

RESEARCH PRODUCT

OSA and cancer in Europe: the European Sleep Apnea Database (ESADA) experience

Athanasia PatakaPawel SliwinskiPaschalis SteiropoulosSofia SchizaRenata L. RihaOzen K. BasogluRichard StaatsBrian D. KentMaria R. BonsignoreUlla AnttalainenI BouloukakiPavol JoppaJohan VerbraeckenCarolina LombardiJan HednerZoran Dogas

subject

Databasebusiness.industryApneaCancerSleep apneacomputer.software_genremedicine.diseaseMalignancynervous system diseasesrespiratory tract diseasesObstructive sleep apneastomatognathic systemCohortmedicinemedicine.symptombusinesscomputerHypopneaCohort study

description

Background: Experimental and clinical studies suggest a relationship between Obstructive Sleep Apnea (OSA) and cancer development or progression Objectives: To explore the association between the severity of OSA and prevalence of cancer among patients reported to the European Sleep Apnea Database (ESADA) after control of several known risk factors for cancer development Methods: A prospective multicentre cohort study of adult patients with OSA (Apnea/Hypopnea Index, AHI≥5). OSA severity was classified according to AHI, Oxygen Desaturation Index (ODI) and % night-time spent with oxygen saturation Results: Of 19,556 participants, 357 (1.8%, 59.4% male) had been diagnosed with malignancy. Patients with malignancy were older (p Conclusion: In the large multicentric ESADA cohort there was an association between OSA (AHI cutoff 5) and a prevalent cancer diagnosis but only in patients aged below 50 years.

yearjournalcountryeditionlanguage
2017-09-01Sleep and Control of Breathing
https://doi.org/10.1183/1393003.congress-2017.oa3209