6533b862fe1ef96bd12c6d6e
RESEARCH PRODUCT
From Mannose to Small Amphiphilic Polyol: Perfect Linearity Leads To Spontaneous Aggregation
Johannes M. DieterichAnssi PeuronenJanne RuokolainenReko LeinoTiina SalorantaManu Lahtinensubject
X ray diffractionAb initioMannosed-mannose010402 general chemistry01 natural sciencesspontaneous aggregationchemistry.chemical_compoundPolyolAmphiphileGeneral Materials Scienceta116Nuclear magnetic resonance spectroscopychemistry.chemical_classificationpolyolsta114010405 organic chemistryChemistrySubstrate (chemistry)General ChemistryNuclear magnetic resonance spectroscopySelf assemblyCondensed Matter Physics0104 chemical sciencesCrystallographyX-ray crystallographySelf-assemblydescription
Terminally unsaturated and diastereochemically pure polyol derived from d-mannose shows spontaneous aggregation behavior in water solution. In order to study and clarify this unforeseen phenomenon, a conformational study based on NMR spectroscopy combined with ab initio structure analysis using the COSMO-solvation model was pursued. The results, together with X-ray diffraction studies, suggest a low energy linear conformation for this particular substrate both in solid states and in solution. For such small-sized acyclic carbohydrate derivatives, the linear conformation appears to be a key prerequisite for the unusual molecular self-assembly reported herein. peerReviewed
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2016-01-05 | Crystal Growth & Design |