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RESEARCH PRODUCT

Effect of a traditional Mediterranean diet on apolipoproteins B, A-I, and their ratio: a randomized, controlled trial.

Valentina Ruiz-gutiérrezEmilio RosDolores CorellaJosé LapetraJordi Salas-salvadóJulia WärnbergJulia WärnbergRosa SolàMontserrat FitóLuis Serra-majemValentini KonstantinidouFernando ArósElena CasalsRamon EstruchMiguel-angel Martínez-gonzálezMiguel Angel MuñozMaría-isabel CovasRafael De La TorreM.c. López-sabaterMiquel FiolPilar Buil-cosiales

subject

MaleApolipoprotein BMediterranean dietCoronary DiseaseDiet MediterraneanDieta mediterràniaApolipoprotein B/A-I ratiolaw.inventionCohort StudiesRandomized controlled triallawVirgin olive oilMedicineNutsCardiometabolic riskAged 80 and overBioquímica y tecnologíabiologyAnthropometryMiddle AgedLipidsBiochemistry and technology0021-9150virgin olive oilApolipoproteïnesFemalelipids (amino acids peptides and proteins)Cardiology and Cardiovascular MedicineApolipoprotein BCohort studyRiskmedicine.medical_specialtyApolipoprotein B/A-IBioquímica i biotecnologiaInternal medicineMediterranean dietHumansPlant OilsOlive OilAgedApolipoproteins BApolipoprotein A-Ibusiness.industrynutritional and metabolic diseasesApolipoproteins bCardiometabolic riskClinical trialEndocrinologybiology.proteinbusinessOlive oil

description

Objectives: Apolipoprotein (Apo)B, ApoA-I, and their ratio could predict coronary heart disease (CHD) risk more accurately than conventional lipid measurements. Our aim was to assess the effect of a traditional Mediterranean diet (TMD) on apolipoproteins. Methods: High-cardiovascular risk subjects (n=551, 308 women and 243 men), aged 55-80 years, were recruited into a large, multicenter, randomized, controlled, parallel-group, clinical trial (The PREDIMED Study) aimed at testing the efficacy of TMD on primary cardiovascular disease prevention. Participants assigned to a low-fat diet (control) (n=177), or TMDs (TMD. +. virgin olive oil (VOO), n=181 or TMD. +. nuts, n=193) received nutritional education and either free VOO (ad libitum) or nuts (dose: 30. g/day). A 3-month evaluation was performed. Results: Both TMDs promoted beneficial changes on classical cardiovascular risk factors. ApoA-I increased, and ApoB and ApoB/ApoA-I ratio decreased after TMD. +. VOO, the changes promoting a lower cardiometabolic risk. Changes in TMD. +. VOO versus low-fat diet were -2.9. mg/dL (95% CI, -5.6 to -0.08), 3.3. mg/dL (95% CI, 0.84 to 5.8), and -0.03. mg/dL (-0.05 to -0.01) for ApoB, ApoA-I, and ApoB/ApoA-I ratio, respectively. Conclusions: Individuals at high-cardiovascular risk who improved their diet toward a TMD pattern rich in virgin olive oil, reduced their Apo B and ApoB/ApoA-I ratio and improved ApoA-I concentrations. © 2011 Elsevier Ireland Ltd.

yearjournalcountryeditionlanguage
2011-09-01
http://hdl.handle.net/20.500.11797/PC1777