6533b862fe1ef96bd12c6f2e

RESEARCH PRODUCT

Circadian rhythms and chemical carcinogenesis: Potential link. An overview.

Barbara Oesch-bartlomowiczFranz OeschCarsten WeissCornelia Dietrich

subject

DNA RepairDNA repairDNA damageHealth Toxicology and MutagenesisCell Cycle ProteinsBiologymedicine.disease_causeNeoplasmsGeneticsmedicineHomeostasisHumansAnimalsCircadian rhythmOrganismCell CyclePeriod Circadian ProteinsDNACell biologyCircadian RhythmCLOCKNuclear receptorCarcinogensPeriod Circadian ProteinsCarcinogenesisDNA Damage

description

Circadian rhythm is an integral and not replaceable part of the organism's homeostasis. Its signalling is multidimensional, overlooking global networks such as chromatin remodelling, cell cycle, DNA damage and repair as well as nuclear receptors function. Understanding its global networking will allow us to follow up not only organism dysfunction and pathology (including chemical carcinogenesis) but well-being in general having in mind that time is not always on our side. The authors thank ECNIS (Environmental Cancer, Nutrition and Individual Susceptibility), a network of excellence operating within the European Union 6th Framework Program, Priority 5: Food Quality and Safety (Contract no. 513943) for financial support.

yearjournalcountryeditionlanguage
2009-11-01
10.1016/j.mrgentox.2009.10.006