5-Oxo-1,4-dihydroindenopyridines: Calcium modulators with partial calcium agonistic activity

6533b862fe1ef96bd12c74db

RESEARCH PRODUCT

5-Oxo-1,4-dihydroindenopyridines: Calcium modulators with partial calcium agonistic activity

subject

Inotrope Chemistry Stereochemistry Organic Chemistry Michael reaction Agonistic behaviour chemistry.chemical_element Barium Knoevenagel condensation Calcium Guinea pig ileum

description

The title compounds 4a-g were prepared by Knoevenagel reactions of 1,3-indandione (1) with the aromatic aldehydes 2a-g followed by cyclizing Michael addition of the products thus obtained with methyl β-aminocrotonate (3). The structures of products 4 were characterized by spectal data. Positive inotropic activities were observed on electrically stimulated, left atria of giunea pigs and these effects could be attributed to calcium agonism. On the other hand, barium chloride-induced contractions of guinea pig ileum were inhibited in a dose-dependent manner.

year	journal	country	edition	language
1990-02-01	Journal of Heterocyclic Chemistry

https://doi.org/10.1002/jhet.5570270223

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